News

ASCEND2.0 Launches New Idaho-Based Biotech Startup: Tozho LLC

ASCEND2.0, a commercialization initiative overseen by the New Mexico Start-Up Factory (NMSUF), is proud to announce the launch of Tozho LLC, a pioneering new biotech company emerging from research supported by the Idaho ASCEND2.0 program.

Tozho LLC is developing a novel targeted drug delivery technology that utilizes a specialized carrier to transport therapeutics directly to specific locations in the body—offering transformative potential for precision medicine and improved patient outcomes.


The company, led by John Chavez, Managing Director of NMSUF, works to accelerate the path from research to market through entrepreneurial support and investment. As a collaborator assisting for non-dilutive funding, Dr. Ching-An Peng created the Tozho technology, but he is not part of the company.


“This is exactly the kind of translational science ASCEND2.0 was designed to support,” said John Chavez, managing director of NMSUF. “Tozho represents how regionally rooted research can scale into national impact.”


The launch of Tozho highlights the success of ASCEND2.0 in fostering biotech innovation in underserved regions like Idaho and underscores NMSUF’s role in turning early-stage technologies into investable, high-impact companies.


Learn more about the Tozho team and technology here.

TrilliumBiO and T-NeuroDx Announce Strategic Collaboration to Commercialize Blood-Based Biomarkers for Alzheimer’s Disease

TrilliumBiO, a leader in biomarker discovery and precision diagnostics, today announced a strategic collaboration with T-NeuroDx, a pioneering diagnostics company dedicated to developing innovative solutions for detecting neurodegenerative diseases, to advance the development of blood-based biomarker diagnostics for Alzheimer’s disease.

This partnership brings together TrilliumBiO’s expertise in diagnostic assay development and clinical validation with T-NeuroDx’s deep scientific and clinical understanding of Alzheimer’s disease pathology and biomarker discovery. Working together, the companies will co-develop and validate blood-based biomarkers that can support earlier diagnosis—addressing one of the most urgent challenges in neurodegenerative care.

“We are proud to partner with T-NeuroDx to bring more accessible, non-invasive diagnostics to patients and providers,” said Laura Vivian, CEO of TrilliumBiO. “By combining our diagnostic development capabilities with their cutting-edge biomarker science, we aim to help shift Alzheimer’s detection from late-stage confirmation to early, actionable insight.”

Blood-based biomarkers represent a transformative opportunity in Alzheimer’s disease. As part of the strategic partnership, the teams will commercialize T-Neuro’s technology as a Lab Developed Test (LDT) and incorporate it in the evaluation of promising investigational biomarkers that appear earlier in the disease process, designed to support more timely and accessible diagnosis and disease management.

“This partnership accelerates our core mission to advance the early detection of Alzheimer’s disease,” said Michael Reed, Ph.D., Chief Development Officer of T-NeuroDx. “TrilliumBiO’s commitment to providing cutting-edge diagnostic solutions to underserved communities aligns perfectly with our own and strengthens our combined effort to revolutionize early-stage Alzheimer’s care.”

The initiative will include clinical studies across diverse populations, with the goal of supporting regulatory submissions and the commercialization of clinically validated blood tests for Alzheimer’s disease in the coming years.


About TrilliumBiO

TrilliumBiO is a life sciences company specializing in biomarker discovery and the development and commercialization of novel diagnostic tests in collaboration with healthcare innovators. With a proven track record of translating clinical insights into market-ready solutions, TrilliumBiO delivers validated, physician-guided diagnostics that address complex medical challenges. Backed by strong research partnerships and a commitment to evidence-based development, TrilliumBiO transforms discovery into actionable innovations that inform real-world clinical decisions. More information about TrilliumBiO can be found at TrilliumBiO.com.


About T-NeuroDx

T-NeuroDx is an early-stage diagnostics company at the forefront of neurodegenerative disease research, with a primary focus on Alzheimer’s disease. The company is developing a revolutionary diagnostic biomarker that can identify Alzheimer’s disease at its earliest stages before other biomarkers are detectable or useful. The technology is based on the detection of dysfunctional T cells, a disease initiating factor that precedes the accumulation of aggregated amyloid beta and tau proteins, the traditional markers of Alzheimer’s. By enabling early and accurate diagnosis, T-NeuroDx’s innovative biomarker technology has the potential to transform the landscape of Alzheimer’s drug development and patient care. More information about T-NeuroDx can be found at www.TNeuroDx.com.

Osazda Energy’s Chief Engineer Wins Best Poster Award at Prestigious IEEE Photovoltaic Specialists Conference

Osazda Energy is proud to announce that Chief Engineer, Andre Chavez, has been awarded the Best Poster Award for Area 4: Packaging, Reliability, Recyclability, and Supply Chain at the IEEE 53rd Photovoltaic Specialists Conference (PVSC-53).

This award recognizes excellence in research and presentation within a critical area of photovoltaics focused on enhancing the durability, sustainability, and logistical viability of solar technologies. Chavez’s poster stood out among a competitive field of international presenters, offering innovative insights that advance the reliability and long-term performance of photovoltaic systems.


Hosted annually, the IEEE PVSC is one of the world’s premier technical conferences for photovoltaic science and engineering. The event draws leading researchers, industry professionals, and policymakers to share breakthroughs and collaborate on the future of solar energy.

“It’s an honor to be recognized among such a talented and forward-thinking community,” said Chavez. “I’m grateful to the University of New Mexico, Osazda Energy, and our many collaborators for their support in this work.”

Click here to learn more about the IEEE PVSC Poster Contest and this year’s awardees.

General information about the IEEE PVSC conference.

NMSUF Visits University of Hawaiʻi at Mānoa to Highlight Ascend 2.0 Research and Commercialization Progress

Last week, the team behind the NSF-funded ASCEND2.0 program visited the University of Hawaiʻi at Mānoa to engage directly with two of its grantees, Dr. Jesse Owens and Dr. Soojin Jun, whose groundbreaking research is paving the way for innovations in biologic medicine and food preservation.

The visit provided an opportunity for the ASCEND2.0 leadership team to connect in person with both researchers, share a meal, and gain firsthand insight into the impact and advancement of their work. Dr. Owens is developing novel therapeutics to treat inflammatory bowel disease using biologic delivery mechanisms, while Dr. Jun is exploring next-generation food preservation technologies—both of which were highlighted earlier this year when their projects were selected for ASCEND2.0 support. Read more about their research here.

In addition to site visits, the NMSUF team met with members of the University of Hawaiʻi’s technology transfer office, strengthening collaboration around commercialization efforts. The discussions underscored how ASCEND2.0 funding continues to accelerate applied research into real-world solutions by supporting translational work that brings university-based innovations closer to market.

“We were thrilled to see the momentum firsthand and deepen our partnerships with both the investigators and the broader University of Hawaiʻi community,” said the NMSUF team. “Mahalo to our partners for their hospitality and their shared commitment to driving innovation from the lab to the marketplace.”

The ASCEND2.0 program—administered by the New Mexico Startup Factory (NMSUF)—identifies and supports high-potential, university-based research teams, helping them overcome the early-stage commercialization gap through funding, mentorship, and ecosystem building.

For more information on ASCEND2.0 and its current portfolio of innovators, visit ascendtwo.org.

NMSUF Strengthens Ties with ASCEND2.0 University Researchers Advancing Drug Delivery and Parkinson’s Therapies

As part of ASCEND2.0’s ongoing efforts to deepen partnerships with Principal Investigators and their institutions, John Chavez, Director of Program Engagement, recently visited two leading researchers whose work is pushing the boundaries of science in innovative and impactful ways.

At the University of Idaho, Chavez met with Dr. Ching-An Peng, who is pioneering a novel method for isolating plant-derived extracellular vesicles (EVs). Leveraging biodegradable chitin particles and intein-mediated splicing, Dr. Peng’s technique preserves the structural integrity and function of EVs—an advancement that could unlock new possibilities in drug delivery, cancer therapy, agriculture, and beyond. ASCEND2.0 is proud to support Dr. Peng as he advances this cutting-edge research and continues to explore real-world applications for his discoveries.

Learn more: Dr. Ching-An Peng Selected for ASCEND2.0 Cohort

Chavez also traveled to the University of Nevada, Reno to meet with Dr. Ruben Dagda, whose lab is exploring the role of mitochondrial function in neurodegenerative diseases, including Parkinson’s. Dr. Dagda’s research focuses on cellular pathways that protect mitochondrial health—offering potential for new therapeutic approaches that could slow disease progression and protect neurons. The visit provided an opportunity to discuss future collaboration and how ASCEND2.0 can continue to support his promising work.

Learn more: Dr. Ruben Dagda Selected for ASCEND2.0 Cohort

These visits reflect ASCEND2.0’s commitment to building strong relationships with researchers who are advancing bold, solution-driven science. Stay tuned as we continue to spotlight the groundbreaking work of our cohort members and explore new ways to elevate their research and impact.

TNeuro Pharma Announces Publication of Groundbreaking Alzheimer’s Research in Prestigious Journal

ALBUQUERQUE, New Mexico — T-Neuro Pharma, a leading biotechnology company dedicated to developing innovative diagnostics and therapeutics for neurodegenerative diseases, announced the publication of a landmark research article in Proceedings of the National Academy of Sciences(PNAS), a peer-reviewed journal of the National Academy of Sciences. The article, “Antigen-Specific Age-Related Memory CD8 T Cells Induce and Track Alzheimer’s-Like Neurodegeneration,” details a significant breakthrough in understanding the early events and progression of Alzheimer’s disease.

Key Findings:

  • Targeting Early Events in Alzheimer’s: Unlike traditional approaches that focus on the symptoms of Alzheimer’s, such as plaques and tangles, T-Neuro Pharma’s research identifies and targets earlier events in the disease’s progression.
  • Groundbreaking Discovery: The research team has identified a critical event that likely occurs before the formation of plaques and tangles, representing a significant advancement in understanding the disease’s early mechanisms.
  • Role of T Cells in Alzheimer’s: The study reveals that a specific population of Tcells enters the brain and targets neurons, initiating a cascade of events that lead to the hallmark pathologies of Alzheimer’s and cognitive decline.
  • Early Detection in Humans: These T cells not only accumulate in the brains of Alzheimer’s patients, but can also be detected disappearing from blood, enabling the identification of patients early in the disease progression and offering the potential for timely intervention.
  • Future Therapeutic Implications: The findings not only pave the way for early diagnosis, but also open up new avenues for therapeutic development by targeting these T cells, potentially altering the course of the disease and improving patient outcomes.

“This study is the closest we’ve come to identifying a singular factor acting before amyloid and tau — the proteins responsible for brain plaques and tangles — in sporadic Alzheimer’s disease,” says Christopher Wheeler, Ph.D., lead author of the study and CSO of T-Neuro Pharma. “Since this depends on a kind of immune cell that is easy to monitor and control, we can use this to devise new ways to help diagnose and possibly treat Alzheimer’s earlier. More work needs to be done to determine if the approaches inspired by our work can be applied to all patients with non-inherited forms of Alzheimer’s, but early evidence has been very encouraging.”


Kristina Trujillo, Ph.D., CEO of T-Neuro Pharma, says the findings represent a significant step forward in the early detection and intervention of Alzheimer’s, which is vital for improving the quality of life for patients and their families.

“We are excited about the potential impact of this work to ultimately improve a patient’s quality of life and offer hope for a future with more effective treatments,” Trujillo says.


About T-Neuro Pharma

T-Neuro Pharma is a clinical-stage biopharmaceutical company that develops diagnostics and disease-modifying therapies for Alzheimer’s and other neurodegenerative diseases. The company targets the root cause of these devastating conditions, to improve the lives of patients and their families. For more information, please visit the https://tneuropharma.com or @Tneuropharma.com for media interviews.

ORC Tech Presents Cell Phone Signal Booster Technology at IEEE Conference

ORC Tech LLC recently was accepted into the Sandia National Laboratories’ New Mexico Small Business Assistance (NMSBA) program. This opportunity enabled ORC Tech to rigorously test its innovative, passive, and collapsible signal booster technology, leveraging the extensive communications and radar expertise of Dr. John A. McVay from Sandia National Laboratories.

Dr. McVay presented focused data and cell phone signal enhancement information from the ORC Tech collaboration at the 2024 IEEE International Symposium on Antennas and Propagation. This presentation, titled “Wireless Deployable Fresnel Rings Signal Booster,” was given on July 15th, 2024, in Florence, Italy. The discussion focused on a groundbreaking technology initially developed by NASA and licensed by ORC Tech that solved wireless reception challenges astronaut crews face during lunar missions. This presentation displayed significant improvements in signal reception for cell phone users to enhance their communication when cell phone signals are weak.

About ORC Tech LLC: ORC Tech LLC stands at the forefront of technological innovation, developing products that integrate cutting-edge NASA-based technologies. Our range of products, including signal boosters for cell phones, laptops, satellite, and Wi-Fi internet receivers, are designed to enhance local reception without needing power plugs, cables, or batteries. We aim to provide advanced, reliable, and eco-friendly solutions to consumers and industries worldwide.

For more information, please contact: Peter Schmitz – peter@orctech.com 
Website: www.orctech.com

Stay connected with us for the latest updates and developments as we continue to push the boundaries of wireless communication technology.

Peter Schmitz
ORC Tech LLC
+1 773-865-1999
peter@orctech.com

New jobs, bigger facilities, local support: New Mexico’s bioscience industry is alive and kicking – Albuquerque Journal (abqjournal.com)

New jobs, bigger facilities, local support: New Mexico’s bioscience industry is alive and kicking – Albuquerque Journal (abqjournal.com)

Pharmaceutical research, development and manufacturing company Curia broke ground this fall on a $100 million expansion of its Albuquerque operations, potentially adding nearly 300 new local jobs to its current workforce.

It’s the second major expansion here since 2018 by the biotech company, which already employs about 400 people at two locations, including a 135,000-square-foot facility at the Midtown Business Park at I-25 and Montgomery, plus an 80,000-square-foot facility near Balloon Fiesta Park.

Curia’s Oct. 27 groundbreaking coincided with another major biotechnology industry announcement that same week in Las Cruces, where remote health-monitoring services company Electronic Caregiver reported closing on $42.5 million in fresh funding from private investors. That makes a total of $110 million in private equity raised by Electronic Caregiver since launching in 2009.

The new funding will help accelerate the firm’s aggressive expansion plans, which include hiring another 770 employees over the next few years, about 95% of them to be located at the company’s 10-story downtown office tower. The state and the city of Las Cruces provided about $1.2 million in Local Economic Development Act, or LEDA, funding last year to help remodel and equip Electronic Caregiver’s office building, which the firm purchased outright over the summer after leasing space there for more than a decade.

The state also contributed $5 million in LEDA money to Curia for its expansion plans in Albuquerque, with the city expected to kick in another $500,000.

Gov. Michelle Lujan Grisham, who attended Curia’s groundbreaking, said that the company’s investment and expansion plans reflect the state’s growing reputation as a bustling magnet for the life sciences industry.

“New Mexico has become a sophisticated biosciences hub that continues to attract companies leading the way in global science and healthcare,” Lujan Grisham said in a statement. “These are high-paying jobs of the future that will fortify New Mexico’s families and expand economic security for our graduates who want to remain in the state to live and work.”

While big announcements, the Curia and Electronic Caregiver expansions are only the latest developments in New Mexico’s burgeoning bioscience industry, which has grown exponentially over the past decade, and particularly over the past five years, after lawmakers approved the creation of a state-funded Bioscience Authority in 2017 to help promote local industry development. That’s led to more unified public and private efforts to help newly formed startups launch and grow, expand existing businesses, and attract more companies, entrepreneurs and investment capital to the state.

Those efforts are boosted by New Mexico’s vibrant startup ecosystem, which offers broad wrap-around services through incubators, business accelerators and access to early-stage venture funding. That support base has, in turn, inspired local entrepreneurs to turn a lot more biotechnology innovation from the state’s research universities and national labs into marketable products and services.

More work is needed to build on today’s momentum, according to local industry experts, beginning with additional state and private-sector funding to convert fledgling startups and existing businesses into thriving, sustainable enterprises. And to get that ball rolling, the Bioscience Authority is seeking $50 million in state money in this year’s legislative session for a new co-investment fund to allow the Authority to invest jointly in local bioscience companies alongside other venture firms.

Apart from capital, more physical infrastructure — such as incubation labs with high-tech equipment and collaborative office space — is also critical.

But, given the state’s accelerated bioscience development in recent years, local leaders say New Mexico is now approaching a turning point that, with additional statewide efforts, could move the industry from promising momentum to critical mass.

Doug Ziedonis — University of New Mexico Health System CEO and executive vice president for UNM health sciences — called it a “critically important” moment for the local industry.

“We’re at a very exciting point now with our research universities, state agencies, government officials and industry all coming together around strategic plans to push forward,” Ziedonis told the Journal. “… We’ve seen how successful collaborative efforts in such other sectors as the film industry have been, and we know we can do the same in the bioscience arena. We have great momentum and, by working together, we can really grow this industry, not just in Albuquerque, but across the state.”

Steady expansion

New Mexico’s bioscience sector — which includes medical-related products and services, as well as biotechnology for agricultural production and environmental improvement — has been evolving for decades, thanks to continuous innovation and discovery at the state’s research universities and labs, plus entrepreneurial creativity in applying new technologies to real-world problems.

As of 2015, some 700 biotech companies were already operating around the state, directly employing about 9,300 people and supporting up to 41,000 industry-related jobs, according to a report by a “GrowBio” initiative that emerged in 2016 to unite the public and private sectors around policies and incentives to build the industry. Commercial development encompasses everything from new medical devices, diagnostic tools and treatments to improved methods and tools for food production and safety, and innovative use of microbes and enzymes to make manufacturing and chemical processes environmentally friendly.

The sector generated about $1.2 billion in revenue in 2015, according to the report, with such large, well-established institutions as Tricore Reference Laboratories and the Lovelace Respiratory Research Institute in Albuquerque boosting employment numbers and economic impact significantly. But a broad swath of emerging bioscience startups also contributed to industry growth as public and private efforts to build New Mexico’s startup economy gained force.

In particular, the 2013 opening of a BioScience Center in Uptown Albuquerque as the state’s first privately run, dedicated incubator for biotechnology startups marked a turning point. Pharmaceutical industry veteran Stuart Rose opened the center after building a homegrown startup, Oso Biopharmaceuticals, into a major contract research and manufacturing services company in Albuquerque.

New York-based AMRI Global aquired Oso for $110 million in 2014. It’s since rebranded as Curia, the company that just broke ground on a $100 million expansion.

Rose’s 20,000-square-foot BioScience Center reached full occupancy within six months of its opening in January 2013, and has remained full ever since, housing up to 22 startups at any given time.

“The center has maintained 100% occupancy since launching,” said Greg Byrnes, executive director of the NM Biotechnology and Biomedical Association, or NMBio. “There’s always a waiting list to get in.”

Apart from incubating dozens of startups over the years, the center has helped bring industry people together to network and collaborate, which was one of Rose’s original goals.

“When I ran Oso Pharmaceuticals, I learned a lot about many things going on across the state, but most people didn’t know each other, so no one realized the significant level of activity already happening here,” Rose told the Journal. “I saw the potential to create a focal point for people to connect through the BioScience Center.”

By 2017, unified industry-building efforts in general had gained a lot more momentum through GrowBio, an initiative spearheaded largely by NMBio and UNM health sciences, which worked together to gain legislative approval to create the BioScience Authority as a collaborative economic development agency focused on the bioscience industry.

The 13-member Authority — which receives about $300,000 in annual state funding that’s channeled administratively through UNM — includes representatives from the state’s three research universities, plus appointees by the governor and both legislative chambers.

Bioscience Authority

The agency has concentrated on building collaborative relationships to tap into bioscience-related economic development opportunities, said Board Chair Dale Dekker, a founding principal at Dekker/Perich/Sabatini who helped launch the GrowBio initiative.

“We’ve worked to become a forum for building statewide awareness and support about the sector’s potential to diversify the economy,” Dekker told the Journal. “Our board includes industry experts, entrepreneurs, economic development professionals and public officials from around the state.”

In particular, the agency is forging collaborative initiatives on workforce development, in- and out-of-state marketing and promotion, forums and networking activities to connect people and organizations, and joint efforts to help local communities attract bioscience-related investment, said Authority Executive Director Stephanie Tofighi.

In one noteworthy achievement, the agency created an online guide for “community readiness zones” that cities and municipalities can follow to identify existing strengths and needed assets — such as land, buildings and shovel-ready development areas where companies can locate — to build out local “bioscience hubs.” It includes an evaluation process to gain industry recognition as “readiness zones,” with bronze-to-platinum certifications that can boost marketing initiatives.

“It’s for self-evaluation by communities that go through the process with real estate professionals, architects and municipal organizations to evaluate their local landscape,” Tofighi told the Journal. “We’ve now identified and certified sites in Albuquerque, Santa Fe, Las Cruces and Rio Rancho, and we’re working with people in Socorro, Los Alamos, Los Lunas and Santa Ana Pueblo to certify more zones.”

As a trade organization, NMBio is also working closely with the Bioscience Authority to assist local companies in business development, marketing and networking to strengthen and advance the industry. It’s helped especially in raising New Mexico’s visibility nationally and internationally by organizing local delegations to participate in regional and national trade fairs and conferences.

In 2020, it placed a 16-page, $50,000 informational insert about New Mexico’s bioscience development in Site Selection, a premier, global industry publication.

Association membership has increased from just 27 in 2016, when Byrnes became executive director, to more than 100 now.

“The industry is growing significantly,” Byrnes said. “We’ve expanded our national participation and visibility, and we’ve been able to recruit more companies as a result.”

Co-investment fund

Still, to convert today’s momentum into sustainable, long-term industry expansion, the bioscience sector needs more concentrated state assistance and promotion, particularly funding for startups and existing businesses to weather the early stages of commercial development, Byrnes said.

“All other states with strong bioscience industries and commercial hubs have been blessed with state funding to build their industries,” Byrnes said. “We need the state to step up here if we really want to grow New Mexico’s bioscience sector.”

Gov. Lujan Grisham’s administration has included bioscience as one of New Mexico’s key, strategic industries to diversify the economy. But, beyond the Bioscience Authority’s $300,000 annual allocation, the state has yet to earmark specific funding for bioscience sector development, Dekker said.

“We’re making good progress in building out the bioscience ecosystem, but we need to accelerate our efforts with funding to help biotechnology companies build solid foundations in New Mexico,” Dekker told the Journal. “We need to make key investments in this sector as a strategic industry cluster.”

To do that, the Bioscience Authority, NMBio and other industry partners are seeking legislative approval in this year’s session to earmark $50 million in state money for a new co-investment fund to strategically deploy capital into promising local companies in partnership with other venture investors. Under the proposal, the agency would seek experienced private equity firms that commit to investing $2 for every $1 dollar in state funds for targeted investments, effectively tripling deployable co-investment money to $150 million.

A lot of venture funding has already flowed into local bioscience startups through the State Investment Council, which provides some permanent fund money for venture firms that commit to investing in local companies. That includes a $20 million “catalyst fund” that pumped capital into eight different micro funds for early-stage investments in startups, creating a collective, $40-million pool of venture funding when including micro fund-matching dollars.

Some of that money did flow to bioscience startups, helping to create a lot more biotech ventures in recent years. But most of the catalyst money is now already deployed, making it harder for startups to find more funding.

And that money was never earmarked specifically for the bioscience sector, which generally requires more capital than other types of startups to become established.

“Bioscience really needs capital because it takes longer than other industries to create a sustainable product and it’s very expensive,” Tofighi said.

To test the co-investment concept, the Bioscience authority partnered last year with the New Mexico Angels on a $225,000 investment in Albuquerque-based BennuBio, which is marketing superfast cytometers, or cell meters, for medical diagnostics. The agency provided $75,000, with the rest coming from the Angel’s Vintage Fund for early-stage investments.

Not all industry leaders think the co-investment fund is the right way to deploy state capital. Rose, for example, believes funding would be better allocated directly to established venture firms that commit to investing in local bioscience companies, and that the Bioscience Authority should instead focus on seeking state money for economic development initiatives, such as building more incubator and lab space for biotechnology startups.

But Rose says more state funding is critical to keep industry development moving forward, especially as existing companies seek additional capital to grow.

“We’re well positioned now for fairly advanced startups to grow into more mature companies, but not if available venture funding dries up,” Rose said. “We have a lot of the needed ecosystem infrastructure in place now, with good business leadership and promising technologies under development, but when a company seeks larger rounds of follow-on funding to continue growing, they often have to turn to out-of-state venture funds that may demand they move out of New Mexico to be closer to the investors. We need to create more local sources of funding to allow companies to remain here and flourish. We’ve done a lot, but we still need to provide more support for the bioscience industry to reach critical mass.”

TNeuroPharma Receives Novel Patent

FOR IMMEDIATE RELEASE

UNITED STATES PATENT AND TRADEMARK OFFICE APPROVES NOVEL PATENT SUPPORTING THE DIAGNOSIS AND TREATMENT OF ALZHEIMER’S DISEASE LICENSED TO NEW MEXICO-BASED BIOTECH COMPANY


Dr. Christopher Wheeler, Chief Science Officer of TNeuroPharma, is named on the patent, which provides a method for determining the likelihood of late onset Alzheimer’s Disease (LOAD).


NOVEMBER 02, 2022
FOR ADDITIONAL INFORMATION:
KRISTINA TRUJILLO: KRISTINA@TNEUROPHARMA.COM


Albuquerque, NM, October 27th, 2022 – T-Neuro Pharma, a New Mexico-based company that is developing a breakthrough Alzheimer’s diagnostic and therapeutic, has just reached a major milestone. The United States Patent and Trademark Office (USPTO) has approved the claims of a patent that is owned by Cedars-Sinai Medical Center and licensed exclusively to the company entitled “Novel Blood Cell Biomarker for Late-Onset Alzheimer’s Disease (App. No. 15/754,997).” The claims of this patent include the use of T cells for the diagnosis and treatment of Alzheimer’s disease.


“Targeting these T cells is a completely new way of diagnosing and treating Alzheimer’s Disease,” says the company’s CEO, Dr. Kristina Trujillo. “Given the huge failure rate of previous targets like Beta-Amyloid, I believe a new approach is long overdue.”


Physicians and scientists agree that treatments, even lifestyle interventions, for Alzheimer’s Disease will be most effective in the earliest stages of the disease. But typically, Alzheimer’s Disease isn’t detected until long after significant damage to the brain has occurred. This is because diagnostics such as Amyloid PET and Cerebrospinal fluid biomarkers are costly and invasive, and not practical for regular screening. This means that they are not used until after the patient starts showing symptoms, and damage has already been done to the brain.


TNeuroPharma is developing a diagnostic test called “T-Track”, that identifies Alzheimer’s patients early in the disease. The T-Track diagnostic is a simple blood test that could eventually replace costly and invasive diagnostic such as PET scans and cerebrospinal fluid biomarkers. Not only will the test provide a new diagnostic option for patients, it will also improve the clinical trials for Alzheimer’s drugs. The T-Track test will also allow doctors to monitor the efficacy of drugs in real-time. This can cut hundreds of millions of dollars from drug development costs, decades of time and potentially lead to pharmaceutical breakthroughs in the treatment of Alzheimer’s disease. By targeting dysfunctional T-cells, TNeuroPharma’s diagnostic technology can enable early diagnosis of Alzheimer’s – allowing for more effective clinical trials of confirmed AD patients.

This patent validates the progress of the technology licensed to TNeuroPharma and its application as a general method to diagnose Alzheimer’s disease by measuring immune cells in the blood. Researchers at Cedars-Sinai and the company have completed research identifying certain age-related immune cells as causing major recognized features of the disease. Determining levels of these cells in the blood forms the basis of the T-Track diagnostic test. The T-Track diagnostic identified Alzheimer’s disease and related pre-conditions in patients with high accuracy and can be performed using standard clinical laboratory equipment. As such, it is projected to be orders of magnitude cheaper than currently available tests that require highly specialized equipment and analysis. The development of T-Track will thus enable earlier, accurate, and more
widely available diagnosis of Alzheimer’s Disease. T-Track is also the only Alzheimer’s biomarker based on a causal factor. T-Track is currently optimized for Alzheimer’s diagnosis in a majority of patients, with plans in place to further broaden its reach through a partnership with Los Alamos National Laboratory.


“Translating immune-based technologies to benefit individuals with brain and other serious disorders has long been a professional passion of mine” said Dr. Christopher Wheeler. “Overall, our novel technology not only provides the opportunity to detect the disease earlier by monitoring levels of the immune cells that can cause it, but with development, it could also provide the means to treat Alzheimer’s by inhibiting or eliminating these same problematic immune cells.”


The goal at TNeuroPharma is to provide better diagnostic and treatment options for Alzheimer’s patients. Whether sought by pharmaceutical companies conducting clinical trials, primary care physicians, or patient and caregivers themselves, T-Track offers earlier, more accessible diagnosis in a single blood test amenable to screening large populations, as well as providing critical information to patients individually.


TNeuroPharma was established in 2018 with the goal to revolutionize the approach to detecting and treating Alzheimer’s Disease in living patients. The technology was licensed from Cedars-Sinai, where Dr. Wheeler was on faculty before co-founding T-NeuroPharma together with Dr. Kristina Trujillo and John Chavez. TNeuroPharma is a portfolio company under the New Mexico Start-Up Factory, an organization that is focused on supporting entrepreneurs in the journey of taking innovative technologies from idea to industry.


“This issued patent not only validates the science behind the technology, but it also supports the company’s quest to secure industry partners for product development,” said John Chavez, Managing Partner of the New Mexico Start-Up Factory. “We hope to help millions of people through the early detection of Alzheimer’s disease and revolutionize the current methods of treatment.”


For more information about TNeuroPharma, visit www.tneuropharma.com. For more information about LEEP, visit www.nmleep.com. For more information on the New Mexico Start-Up Factory, please visit www.nmsuf.com.


About TNeuroPharma
T-Neuro is an Alzheimer’s biomarker and therapeutic company focusing on early detection by aiming attention on the T cell contribution to the pathology of the disease. The important T cell response can be detected in blood as an early diagnostic tool and blocked as a therapeutic avenue. Effective treatments for Alzheimer’s disease and other neurodegenerative disorders are within reach through TNeuroPharma’s technology and
patented biomarker method. Those seeking diagnostic information, from pharmaceutical companies conducting clinical trials, to memory clinics, primary care physicians, and individual caregivers can more easily identify patients with confirmed Alzheimer’s disease to guide their next steps. –In each scenario, this can save considerable time, expense, and individual turmoil. Most importantly, the technology offers new hope for the detection and eventual treatment of Alzheimer’s disease.


About the New Mexico Start-Up Factory
The New Mexico Start-Up Factory (NMSUF) is a local organization that focuses on developing laboratory technologies from the idea stage to market readiness. In the company’s innovative model, specialists work with scientists looking to commercialize their innovations while building infrastructure and securing early-stage funding. Through the NMSUF program, technologists are coached through the validation of the technology and market and are then paired with the right management team. A commercialization and business plan/model are created and if all signs point to a good market opportunity and promising development, a company is formed. Companies and scientists that successfully complete the educational piece of the program are open to investment from the NMSUF Fund. The New Mexico Start-Up Factory has launched 14 companies over the last 6 years of which 7 are still in development. (www.nmsuf.com)

Editorial: New college school year full of promise for students, NM

BY ALBUQUERQUE JOURNAL EDITORIAL BOARD

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What do University of New Mexico undergrads and UNM-sponsored research in nanotechnology have in common?

This week, they’re the feel-good antidote to the collective anxiety we feel from the woes that seem to perpetually plague New Mexico: homelessness, murders, water shortages, low worker participation, low academic achievement …

You get the picture.

But for the 1,800 students who moved into UNM’s residence halls between Thursday and Sunday in preparation for the fall semester, Albuquerque represents the excitement of a fresh start after two challenging years of pandemic fits that have disrupted learning tracks and social lives.

(That same promise of new beginnings goes for students headed to classes at New Mexico State University in Las Cruces, Western New Mexico University in Silver City, Eastern New Mexico University in Portales, Highlands University in Las Vegas, Northern New Mexico College in Española, New Mexico Institute of Mining and Technology in Socorro and our many branch campuses and two-year college programs.)

“It’s really exciting to see this many faces back on campus,” Megan Chibanga, UNM’s director of student housing and residence life, told the Journal. “It’s much more active and vibrant now that we got everyone back.”

UNM lifted its mask mandate on March 19. Students, faculty and staff are no longer required to wear a mask inside laboratories, studios, libraries, residence halls, dining facilities or the student union building. But they’re still required at health facilities, research spaces and on UNM shuttles, according to the university’s website.

All that could change, of course, if there’s a surge in positive cases, but current conditions provide what so many students crave: a chance for a “real” college experience of rubbing elbows with fellow students — not staring at a computer screen in isolation to listen to a lecture.

The start of school coincides with another bit of good news. UNM researchers have had not one, but two, nanotechnology breakthroughs with commercial applications that could revolutionize dentistry and make it easier for oil and gas producers to eliminate emissions at the wellhead.

One team, headed by nano materials engineer Leisha Armijo-Martin, has developed a remote-controlled, magnetic toothpaste and toothbrush that injects anti-bacterial solutions into the nooks and crannies of gums and teeth. The product is still under development, but a newly created startup, MNT SmartSolutions LLC, is working to put it on store shelves in the next few years.

MNT is one of 15 local companies formed by the New Mexico Startup Factory, which launched 10 years ago to commercialize new technologies from the state’s research universities and national laboratories. The Startup Factory recently signed a license agreement to market the MNT technology with UNM’s Rainforest Innovations, which manages the university’s tech-transfer and economic development programs.

The other innovation is exciting, both because of game-changing product at the center of a partnership and because the partnership offers well remediation with little to no upfront costs.

UNM engineers have created a nanotechnology-based sealant that could offer the oil and gas industry a permanent solution for abandoned, climate-polluting wells. UNM researchers developed the sealant over 10 years, and they’re now marketing it through a new Albuquerque-based startup, TS-Nano, in partnership with two next-generation, blockchain-based development firms, Devvio Inc. and DevvStream Inc.

The two sister companies invested $2.5 million last month in TS-Nano. The companies are now headquartered in Europe, but Albuquerque-based engineers built their original platform technology in New Mexico.

These developments, as well as the new in-person school year, are emblematic of the promise New Mexico’s institutions of higher learning hold for our students and our communities.

This editorial first appeared in the Albuquerque Journal. It was written by members of the editorial board and is unsigned as it represents the opinion of the newspaper rather than the writers.